The A’s and the Toronto Blue Jays open their 2026 MLB regular seasons Friday at Rogers Centre in Toronto, Ontario. First pitch is scheduled for 7:07 p.m. ET (MLB Network). Let’s analyze MLB odds around the A’s vs. Blue Jays odds and make our expert MLB picks and predictions for the best bets.
2025 season series: Blue Jays won 5-2
The A’s posted a 76-86 record in 2025, finishing in fourth place in the AL West. They managed a 40-41 record on the road, while posting an overall run differential of minus-84. The A’s went 14-17 against the AL East Division.
SS Jacob Wilson finished the season batting .311 which was tied for second in MLB. He added 13 HRs, 63 RBIs and a .800 OPS. He’s a cornerstone of this A’s lineup.
The Blue Jays posted an 94-68 record in 2025, finishing atop the AL East. They played in the World Series for the first time in 32 years, losing in in 7 games to the Los Angeles Dodgers. Toronto were 54-27 at home, and they posted a plus-77 run differential overall in 2025. The Blue Jays went 19-12 against the AL West Division.
RF George Springer is coming off of a career season in 2025, finishing with a .309 batting average, belting 32 HRs, driving in 84 runs and posting a .959 OPS.
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A’s at Blue Jays projected starters
RHP Luis Severino vs. RHP Kevin Gausman
Severino (8-11, 4.54 ERA) made 29 starts in 2025. He had a 1.30 WHIP, 2.8 BB/9 and 6.9 K/9 in 162 2/3 innings.
Pitched twice for Team Dominican Republic in World Baseball Classic (1-0, 2.45 ERA, 7 1/3 IP, 8 H, 2 ER, 11 K)
Only 2025 start vs. Blue Jays: Loss, 4 2/3 IP, 5 R (1 ER), 7 H, 2 BB, 8 K in 76 home loss July 1
Career vs. Blue Jays: 6-4, 3.86 ERA (84 IP, 40 R (36 ER), 1.25 WHIP, 10.9 K/9 in 19 appearances (16 starts)
2025 home stats: 6-2, 3.02 ERA (80 1/3 IP, 32 R (27 ER), 6 HR, 21 BB, 56 K in 14 starts
Gausman (10-11, 3.59 ERA) made 32 starts in 2025. He had a 1.06 WHIP, 2.3 BB/9 and 8.8 K/9 in 193 innings.
2025 vs. A’s: 0-1, 5.59 ERA (9 2/3 IP, 7 R (6 ER), 13 H, 1 HR, 4 BB, 9 K in 2 starts
Career vs. A’s: 2-4, 3.00 ERA (60 IP, 24 R (7 ER), 1.17 WHIP, 9.8 K/9 in 10 starts
2025 home stats: 5-5, 3.86 ERA (95 2/3 IP, 41 ER), 14 HR, 21 BB, 102 K in 16 starts
A’s at Blue Jays odds
Provided by BetMGM Sportsbook; access USA TODAY Sports Scores and Sports Betting Odds hub for a full list. Lines last updated at 12:92 a.m. ET.
Moneyline (ML): A’s +140 (bet $100 to win $140) | Blue Jays -165 (bet $165 to win $100)
Run line (RL)/Against the spread (ATS): A’s +1.5 (-150) | Blue Jays -1.5 (+125)
Over/Under (O/U): 8.5 (O: -115 | U: -105)
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A’s at Blue Jays picks and predictions
Prediction
Blue Jays 5, A’s 2
Moneyline
I like the Blue Jays (-165) to win on Opening Day at Rogers Centre, but not at these odds.
Run line/Against the spread
BET BLUE JAYS -1.5 (+125).
The Blue Jays should get a major lift Friday at Rogers Centre while raising their AL banner. The lineup adds serious pop with 3B Kazuma Okamoto signed from Japan joining 1B Vladimir Guerrero Jr., who’s had success (.357) vs. Severino.
Toronto’s offense is deeper and more explosive, while its pitching staff holds a clear edge. The Athletics are still developing after a 76-win season. With the energy, matchup edge and talent gap, this lines up well for a multi-run win.
Over/Under
PASS.
It’s tough to trust totals this early. Timing at the plate can lag on Opening Day, and pitching often has the edge early. There’s no official play here, but if you’re getting involved, the lean is toward the Under 8.5 (-105) based on the matchup and typical slow starts.
For more sports betting picks and tips, check out SportsbookWire.com and BetFTW.
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